Although enlargement and involvement of the internal auditory canal (IAC) is a common sign of schwannomas of the CPA, these features can also be seen in meningioma. Among intracranial meningiomas, 5%–10% are located in the cerebellopontine angle (CPA), thus comprising the second most common tumors in this anatomic region. Meningiomas account for 26% of primary intracranial neoplasms. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper.įunding: This research was supported by National Natural Science Foundation of China (81271541 to J.P. Received: SeptemAccepted: FebruPublished: April 7, 2015Ĭopyright: © 2015 Gao et al. PLoS ONE 10(4):Īcademic Editor: Karl Herholz, University of Manchester, UNITED KINGDOM Patients with intruding IAC were significantly older (54.5☙.54 years, P=0.021) and had the lowest postoperative residual tumor values (42%, χ 2=7.865, P= 0.005), while those with filled IAC were more likely to be female (95%, χ 2=9.404, P=0.009).Our observations provide the basis for a morphological classification of IAC involvement by CPA meningiomas and further insight into the clinical features of these tumors.Ĭitation: Gao K, Ma H, Cui Y, Chen X, Ma J, Dai J (2015) Meningiomas of the Cerebellopontine Angle: Radiological Differences in Tumors with Internal Auditory Canal Involvement and Their Influence on Surgical Outcome. Peritumoral edema was a risk factor for IAC involvement ( P=0.016, OR=2.186). The results showed that the 71 patients (36.8%) with IAC involvement had a higher ratio of peritumoral edema (χ 2=5.922, P=0.015), postoperative residual tumor (χ 2=22.183, P< 0.001), and a predominance of the meningothelial subtype (χ 2=5.89, P=0. Patient age, sex, tumor volume, postoperative residual tumor, and pathological subtype were compared in patients with and without IAC involvement by the tumor and among the different types of IAC involvement. The pre- and postoperative MR images of 193 consecutive patients with pathologically diagnosed meningioma centered around the IAC were analyzed, focusing on changes in the IAC, maximal axial tumor volume, peritumoral brain edema, and postoperative residual tumor. If you think you may have a medical emergency, call your physician or 911 immediately.This study explored the clinical, radiological, and pathological characteristics of cerebellopontine angle (CPA) meningiomas with internal auditory canal (IAC) involvement. By using this Site you agree to the following Terms and Conditions. We offer this Site AS IS and without any warranties. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only.
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